Preferred Name

Rasburicase
Synonyms
Definitions

A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C2404

Accepted_Therapeutic_Use_For

Chemotherapy-induced acute hyperuricemia, treatment and prophylaxis

ALT_DEFINITION

A drug used to treat high blood levels of uric acid in patients with leukemia, lymphoma, and other types of cancer who are receiving certain types of cancer treatment. It is also being studied in the treatment of other medical conditions. Elitek is a type of recombinant enzyme and a type of urate-lowering drug.

CAS_Registry

134774-45-1

code

C2404

Contributing_Source

CTRP

FDA

definition

A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04)

Display_Name

Rasburicase

FDA_UNII_Code

08GY9K1EUO

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

label

Rasburicase

Legacy Concept Name

Rasburicase

NCI_Drug_Dictionary_ID

299001

NSC Number

721631

PDQ_Closed_Trial_Search_ID

299001

PDQ_Open_Trial_Search_ID

299001

Preferred_Name

Rasburicase

prefixIRI

NCIT:C2404

prefLabel

Rasburicase

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

UMLS_CUI

C0937932

subClassOf

http://purl.obolibrary.org/obo/NCIT_C921

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