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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Rasburicase | |
| Synonyms |
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| Definitions |
A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2404 |
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| Accepted_Therapeutic_Use_For |
Chemotherapy-induced acute hyperuricemia, treatment and prophylaxis
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| ALT_DEFINITION |
A drug used to treat high blood levels of uric acid in patients with leukemia, lymphoma, and other types of cancer who are receiving certain types of cancer treatment. It is also being studied in the treatment of other medical conditions. Elitek is a type of recombinant enzyme and a type of urate-lowering drug.
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| CAS_Registry |
134774-45-1
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| code |
C2404
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| Contributing_Source |
CTRP FDA
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| definition |
A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04)
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| Display_Name |
Rasburicase
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| FDA_UNII_Code |
08GY9K1EUO
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| label |
Rasburicase
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|
| Legacy Concept Name |
Rasburicase
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| NCI_Drug_Dictionary_ID |
299001
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| NSC Number |
721631
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| PDQ_Closed_Trial_Search_ID |
299001
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| PDQ_Open_Trial_Search_ID |
299001
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| Preferred_Name |
Rasburicase
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|
| prefixIRI |
NCIT:C2404
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| prefLabel |
Rasburicase
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0937932
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| subClassOf |
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