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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2381
http://purl.obolibrary.org/obo/NCIT_C2381
|
|---|---|
| Preferred Name | Etanercept |
| Definitions |
A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04) |
|---|---|
| prefLabel | Etanercept
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| label | Etanercept
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| PDQ_Closed_Trial_Search_ID | 257809
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| code | C2381
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| Has_Target | |
| prefixIRI | NCIT:C2381
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| in_subset |
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| Display_Name | Etanercept
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| Preferred_Name | Etanercept
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| FDA_UNII_Code | OP401G7OJC
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Etanercept
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| CAS_Registry | 185243-69-0
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| NCI_Drug_Dictionary_ID | 257809
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| Legacy Concept Name | Etanercept
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| type | |
| ALT_DEFINITION | A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 257809
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| Accepted_Therapeutic_Use_For | juvenile arthritis; psoriatic arthritis; rheumatoid arthritis.
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0717758
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