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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2378
http://purl.obolibrary.org/obo/NCIT_C2378
|
|---|---|
| Preferred Name | Vinfosiltine |
| Definitions |
An aminophosphonate derivative of a vinca alkaloid with potential antineoplastic activity. Vinfosiltine exerts its antineoplastic action just like its parent compound, vinblastine, by immobilizing tubulin molecules, thereby interrupting microtubule assembly/disassembly dynamics. As a result, vinfosiltine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An aminophosphonate derivative of a vinca alkaloid with potential antineoplastic activity. Vinfosiltine exerts its antineoplastic action just like its parent compound, vinblastine, by immobilizing tubulin molecules, thereby interrupting microtubule assembly/disassembly dynamics. As a result, vinfosiltine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase. |
|---|---|
| prefLabel | Vinfosiltine
|
| label | Vinfosiltine
|
| PDQ_Closed_Trial_Search_ID | 41716
|
| code | C2378
|
| prefixIRI | NCIT:C2378
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| in_subset | |
| Preferred_Name | Vinfosiltine
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| FDA_UNII_Code | AW1UYE6Q9I
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| Contributing_Source | FDA
|
| Chemical_Formula | C51H72N5O10P
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| Maps_To | Vinfosiltine
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| CAS_Registry | 123286-00-0
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| NCI_Drug_Dictionary_ID | 41716
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| Legacy Concept Name | Vinfosiltine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41716
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0084429
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| Delete | Subject | Author | Type | Created |
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