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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2367
http://purl.obolibrary.org/obo/NCIT_C2367
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|---|---|
| Preferred Name | Triazene Derivative CB10-277 |
| Definitions |
A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04) |
|---|---|
| prefLabel | Triazene Derivative CB10-277
|
| label | Triazene Derivative CB10-277
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| PDQ_Closed_Trial_Search_ID | 41154
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| code | C2367
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| prefixIRI | NCIT:C2367
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| in_subset | |
| Preferred_Name | Triazene Derivative CB10-277
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| Maps_To | Triazene Derivative CB10-277
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| NSC Number | 208107
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| NCI_Drug_Dictionary_ID | 41154
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| Legacy Concept Name | CB10-277
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| PubMedID_Primary_Reference | phase II trial shown to be inactive; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394365/
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41154
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0088835
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