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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C235
http://purl.obolibrary.org/obo/NCIT_C235
|
|---|---|
| Preferred Name | Aminopterin |
| Definitions |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|---|---|
| prefLabel | Aminopterin
|
| label | Aminopterin
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:22526
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| PDQ_Closed_Trial_Search_ID | 39141
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| code | C235
|
| prefixIRI | NCIT:C235
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| in_subset | |
| Preferred_Name | Aminopterin
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| FDA_UNII_Code | JYB41CTM2Q
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| Contributing_Source | FDA
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| Chemical_Formula | C19H20N8O5
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| Maps_To | Aminopterin
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| CAS_Registry | 54-62-6
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| NSC Number | 739
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| NCI_Drug_Dictionary_ID | 39141
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| Legacy Concept Name | Aminopterin
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antimetabolites.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39141
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0002583
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| Delete | Subject | Author | Type | Created |
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