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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2344
http://purl.obolibrary.org/obo/NCIT_C2344
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|---|---|
| Preferred Name | Camptothecin Sodium |
| Definitions |
The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04) |
|---|---|
| prefLabel | Camptothecin Sodium
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| label | Camptothecin Sodium
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| code | C2344
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| prefixIRI | NCIT:C2344
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| in_subset | |
| Preferred_Name | Camptothecin Sodium
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| FDA_UNII_Code | 3L6CT9UWOM
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| Contributing_Source | FDA
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| Maps_To | Camptothecin Sodium
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| CAS_Registry | 25387-67-1
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| NSC Number | 100880
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| Legacy Concept Name | Camptothecin_Sodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1516156
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