Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Imipenem-Cilastatin Sodium
Synonyms
Definitions

A parenteral antibiotic preparation containing imipenem and cilastatin sodium with bactericidal activity. Imipenem, a broad spectrum beta-lactam antibiotic, binds to penicillin-binding proteins (PBP) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. Cilastatin sodium is added to reduce breakdown of imipenem by kidney dehydropeptidase. This agent is effective against both gram positive and negative bacteria and is often used in treating severe infections caused by multiresistant organisms.
ID

http://purl.obolibrary.org/obo/NCIT_C2338
code

C2338
definition

A parenteral antibiotic preparation containing imipenem and cilastatin sodium with bactericidal activity. Imipenem, a broad spectrum beta-lactam antibiotic, binds to penicillin-binding proteins (PBP) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. Cilastatin sodium is added to reduce breakdown of imipenem by kidney dehydropeptidase. This agent is effective against both gram positive and negative bacteria and is often used in treating severe infections caused by multiresistant organisms.
label

Imipenem-Cilastatin Sodium
Legacy Concept Name

Imipenem-Cilastatin_Sodium
NCI_Drug_Dictionary_ID

40786
NSC Number

717864
PDQ_Closed_Trial_Search_ID

40786
PDQ_Open_Trial_Search_ID

40786
Preferred_Name

Imipenem-Cilastatin Sodium
prefixIRI

NCIT:C2338
prefLabel

Imipenem-Cilastatin Sodium
Semantic_Type

Organic Chemical

Antibiotic
UMLS_CUI

C0733696
subClassOf

http://purl.obolibrary.org/obo/NCIT_C260
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