Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Estradiol
Synonyms
Definitions

The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.
ID

http://purl.obolibrary.org/obo/NCIT_C2295
Accepted_Therapeutic_Use_For

Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis
ALT_DEFINITION

A form of the hormone estrogen.
CAS_Registry

50-28-2
CHEBI_ID

CHEBI:16469
code

C2295
Contributing_Source

CTRP
definition

The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.
Display_Name

Estradiol
in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C142799
label

Estradiol
Legacy Concept Name

Estradiol
Preferred_Name

Estradiol
prefixIRI

NCIT:C2295
prefLabel

Estradiol
Semantic_Type

Organic Chemical

Hormone
UMLS_CUI

C0014912
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2293
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http://purl.bioontology.org/ontology/SNMI/F-B2720 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0014912 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Estradiol GALEN LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00648 COID LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/126172005 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D06.472.334.851.437.500 RH-MESH LOOM
http://purl.jp/bio/4/id/200906070304432882 IOBC LOOM
http://localhost/plosthes.2017-1#7694 PLOSTHES LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2295 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.365.415.248 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0014912 ONTOAD LOOM
http://stirdf.jst.go.jp/id/200907084084692459 IOBC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Estradiol APAONTO LOOM
http://purl.bioontology.org/ontology/CPT/82670 CPT LOOM
http://purl.bioontology.org/ontology/VANDF/4017609 VANDF LOOM
http://www.drugbank.ca/drugs/DB00783 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4674 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/001265 NDDF LOOM
http://purl.bioontology.org/ontology/ATC/G03CA03 ATC LOOM
http://www.projecthalo.com/aura#Estradiol AURA LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004958 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145989 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D004958 MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB00783 DINTO LOOM
http://purl.bioontology.org/ontology/LNC/LP14497-9 LOINC LOOM
https://go.drugbank.com/drugs/DB00783 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP69846-1 LOINC LOOM
http://purl.bioontology.org/ontology/MEDDRA/10015499 MEDDRA LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003161 LOINC LOOM
http://www.semanticweb.org/ontologies/epo.owl#Estradiol EPO LOOM
http://purl.bioontology.org/ontology/CSP/1065-4715 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/4083 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 OBI LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 BAO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 GSSO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 ZP LOOM
http://purl.obolibrary.org/obo/CHEBI_23965 OBA LOOM
http://purl.jp/bio/10/gmo/GMO_001264 GMO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018627 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/OMIT_0006189 OMIT LOOM