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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/NCIT_C2265
http://purl.obolibrary.org/obo/NCIT_C2265
|
|---|---|
| Preferred Name | Prasterone |
| Definitions |
A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04) |
|---|---|
| label |
Prasterone
|
| prefLabel |
Prasterone
|
| Legacy Concept Name |
Therapeutic_Dehydroepiandrosterone
|
| in_subset |
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|
| Preferred_Name |
Prasterone
|
| Chemical_Formula |
C19H28O2
|
| Display_Name |
Prasterone
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| PDQ_Open_Trial_Search_ID |
42419
|
| UMLS_CUI |
C0011185
|
| FDA_UNII_Code |
459AG36T1B
|
| prefixIRI |
NCIT:C2265
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| Accepted_Therapeutic_Use_For |
Adrenal insufficiency, replacement; Systemic lupus erythematosus, treatment and steroid treatment reduction
|
| NCI_Drug_Dictionary_ID |
42419
|
| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| CHEBI_ID |
CHEBI:28689
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| Has_Salt_Form | |
| code |
C2265
|
| type | |
| ALT_DEFINITION |
A substance being studied in the prevention of cancer. It is a type of steroid.
|
| NSC Number |
9896
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| PDQ_Closed_Trial_Search_ID |
42419
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| CAS_Registry |
53-43-0
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