Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2246
http://purl.obolibrary.org/obo/NCIT_C2246
Preferred Name

Tariquidar
Definitions
An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)
prefLabel
Tariquidar
label
Tariquidar
PDQ_Closed_Trial_Search_ID
37877
code
C2246
Has_Target
prefixIRI
NCIT:C2246
in_subset
Display_Name
Tariquidar
Preferred_Name
Tariquidar
FDA_UNII_Code
J58862DTVD
Contributing_Source
CTRP
FDA
Chemical_Formula
C38H38N4O6
Maps_To
Tariquidar
CAS_Registry
206873-63-4
NCI_Drug_Dictionary_ID
37877
Legacy Concept Name
Tariquidar
type
ALT_DEFINITION
A substance that is being studied in the treatment of cancer. It may help tumor cells respond again to drugs they have become resistant (unable to respond) to. Tariquidar is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
37877
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0879444
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