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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2242
http://purl.obolibrary.org/obo/NCIT_C2242
|
|---|---|
| Preferred Name | Triapine |
| Definitions |
A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. (NCI04) |
|---|---|
| prefLabel | Triapine
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| label | Triapine
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| PDQ_Closed_Trial_Search_ID | 37830
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| code | C2242
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| Has_Target | |
| prefixIRI | NCIT:C2242
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| in_subset |
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| Display_Name | Triapine
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| Preferred_Name | Triapine
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| FDA_UNII_Code | U4XIL4091C
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Triapine
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| CAS_Registry | 236392-56-6
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| NSC Number | 663249
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| NCI_Drug_Dictionary_ID | 37830
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| Legacy Concept Name | Triapine
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 37830
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0210403
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