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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2235
http://purl.obolibrary.org/obo/NCIT_C2235
|
|---|---|
| Preferred Name | PR1 Leukemia Peptide Vaccine |
| Definitions |
A cancer vaccine containing PR1, a 9 amino-acid human leukocyte antigen (HLA)-A2 restricted peptide derived from proteinase 3, with potential immunotherapeutic activity. Vaccination with PR1 leukemia peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing proteinase 3, resulting in tumor cell lysis. Often overexpressed in leukemic cells, proteinase 3 is a serine proteinase that activates progelatinase A and is involved in angiogenesis and metastasis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cancer vaccine containing PR1, a 9 amino-acid human leukocyte antigen (HLA)-A2 restricted peptide derived from proteinase 3, with potential immunotherapeutic activity. Vaccination with PR1 leukemia peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing proteinase 3, resulting in tumor cell lysis. Often overexpressed in leukemic cells, proteinase 3 is a serine proteinase that activates progelatinase A and is involved in angiogenesis and metastasis. |
|---|---|
| prefLabel | PR1 Leukemia Peptide Vaccine
|
| label | PR1 Leukemia Peptide Vaccine
|
| PDQ_Closed_Trial_Search_ID | 37873
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| code | C2235
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| Has_Target | |
| prefixIRI | NCIT:C2235
|
| in_subset |
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| Display_Name | PR1 Leukemia Peptide Vaccine
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| Preferred_Name | PR1 Leukemia Peptide Vaccine
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| FDA_UNII_Code | 54XUF2TZ7G
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| Contributing_Source |
CTRP
FDA
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| Maps_To | PR1 Leukemia Peptide Vaccine
|
| CAS_Registry | 182253-77-6
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| NSC Number | 698102
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| NCI_Drug_Dictionary_ID | 37873
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| Legacy Concept Name | PR1_Leukemia_Peptide_Vaccine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 37873
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C0879440
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