Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2228
http://purl.obolibrary.org/obo/NCIT_C2228
Preferred Name

Apolizumab
Definitions
A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro. (NCI04)
prefLabel
Apolizumab
label
Apolizumab
PDQ_Closed_Trial_Search_ID
38451
code
C2228
Has_Target
prefixIRI
NCIT:C2228
in_subset
Display_Name
Apolizumab
Preferred_Name
Apolizumab
FDA_UNII_Code
G88KCP51RE
Contributing_Source
CTRP
FDA
Maps_To
Apolizumab
CAS_Registry
267227-08-7
NSC Number
704867
710066
NCI_Drug_Dictionary_ID
38451
Legacy Concept Name
Apolizumab
type
ALT_DEFINITION
A substance being studied in the treatment of hematologic (blood) cancers. Apolizumab binds to a protein called ID10, which is found on the surface of some types of immune cells and cancer cells. It may help the immune system kill cancer cells. It is a type of monoclonal antibody.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38451
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
UMLS_CUI
C1122758
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