Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2213
http://purl.obolibrary.org/obo/NCIT_C2213
Preferred Name

Liposomal Daunorubicin Citrate
Definitions
A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.
label
Liposomal Daunorubicin Citrate
prefLabel
Liposomal Daunorubicin Citrate
Legacy Concept Name
Liposomal_Daunorubicin_Citrate
in_subset
Preferred_Name
Liposomal Daunorubicin Citrate
Is_Value_For_GDC_Property
Display_Name
Liposomal Daunorubicin Citrate
Maps_To
Liposomal Daunorubicin Citrate
PDQ_Open_Trial_Search_ID
37796
Has_Target
UMLS_CUI
C0717668
prefixIRI
NCIT:C2213
Accepted_Therapeutic_Use_For
Acute Nonlymphocytic Leukemia; Acute Lymphocytic Leukemia; Advanced HIV-associated Karposi Sarcoma.
NCI_Drug_Dictionary_ID
37796
Contributing_Source
CTRP
PCDC
subClassOf
Is_PCDC_AML_Permissible_Value_For_Variable
code
C2213
type
NSC Number
697732
PDQ_Closed_Trial_Search_ID
37796
Semantic_Type
Organic Chemical
Antibiotic
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