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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2203
http://purl.obolibrary.org/obo/NCIT_C2203
|
|---|---|
| Preferred Name | Acridine Carboxamide |
| Definitions |
A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death. |
|---|---|
| prefLabel | Acridine Carboxamide
|
| label | Acridine Carboxamide
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| PDQ_Closed_Trial_Search_ID | 37776
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| code | C2203
|
| prefixIRI | NCIT:C2203
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| in_subset | |
| Preferred_Name | Acridine Carboxamide
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| FDA_UNII_Code | 0N3V8R4E13
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| Contributing_Source | FDA
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| Maps_To | Acridine Carboxamide
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| CAS_Registry | 89459-25-6
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| NCI_Drug_Dictionary_ID | 37776
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| Legacy Concept Name | Acridine_Carboxamide
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 37776
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0919282
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| Delete | Subject | Author | Type | Created |
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