Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C2194 http://purl.obolibrary.org/obo/NCIT_C2194
Preferred Name	Sorafenib Tosylate
Definitions	The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.
Type	http://www.w3.org/2002/07/owl#Class

definition	The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.
prefLabel	Sorafenib Tosylate
label	Sorafenib Tosylate
CHEBI_ID	CHEBI:50928
PDQ_Closed_Trial_Search_ID	299013
code	C2194
Has_Target	http://purl.obolibrary.org/obo/NCIT_C17476 http://purl.obolibrary.org/obo/NCIT_C17484 http://purl.obolibrary.org/obo/NCIT_C26203 http://purl.obolibrary.org/obo/NCIT_C17328 http://purl.obolibrary.org/obo/NCIT_C26202 http://purl.obolibrary.org/obo/NCIT_C28496 http://purl.obolibrary.org/obo/NCIT_C30164 See more See less
prefixIRI	NCIT:C2194
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Sorafenib Tosylate
Preferred_Name	Sorafenib Tosylate
FDA_UNII_Code	5T62Q3B36J
Contributing_Source	CTRP FDA
Chemical_Formula	C21H16ClF3N4O3.C7H8O3S
Maps_To	Sorafenib Tosylate
CAS_Registry	475207-59-1
NSC Number	724772
NCI_Drug_Dictionary_ID	299013
Legacy Concept Name	BAY_43-9006
Has_Free_Acid_Or_Base_Form	http://purl.obolibrary.org/obo/NCIT_C61948
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C93259 http://purl.obolibrary.org/obo/NCIT_C159199 http://purl.obolibrary.org/obo/NCIT_C129825 http://purl.obolibrary.org/obo/NCIT_C2336
PDQ_Open_Trial_Search_ID	299013
Accepted_Therapeutic_Use_For	Major Depressive Disorder Advanced renal cell carcinoma; Metastatic Colorectal Cancer
Semantic_Type	Organic Chemical Pharmacologic Substance
UMLS_CUI	C1676709

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