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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2186
http://purl.obolibrary.org/obo/NCIT_C2186
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|---|---|
| Preferred Name | Diarylsulfonylurea Compound |
| Definitions |
A sulfonylurea compound containing aryl groups with potential antineoplastic activity. Originally developed as herbicides, diarylsulfonylureas have shown a broad spectrum of antitumor activity in vivo. The precise mechanism of antitumor action has not yet been elucidated, however, certain diarylsulfonylurea compounds have been shown in preliminary studies to exert antimitotic effects through their inhibition of tubulin polymerization, and others have been shown to be effective antitumor agents in animal models by the mechanism of uncoupling mitochondrial oxidative phosphorylation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A sulfonylurea compound containing aryl groups with potential antineoplastic activity. Originally developed as herbicides, diarylsulfonylureas have shown a broad spectrum of antitumor activity in vivo. The precise mechanism of antitumor action has not yet been elucidated, however, certain diarylsulfonylurea compounds have been shown in preliminary studies to exert antimitotic effects through their inhibition of tubulin polymerization, and others have been shown to be effective antitumor agents in animal models by the mechanism of uncoupling mitochondrial oxidative phosphorylation. |
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| prefLabel | Diarylsulfonylurea Compound
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| label | Diarylsulfonylurea Compound
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| code | C2186
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| prefixIRI | NCIT:C2186
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| Preferred_Name | Diarylsulfonylurea Compound
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| Legacy Concept Name | Diarylsulfonylurea_Compound
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| type | |
| subClassOf | |
| Semantic_Type | Chemical Viewed Structurally
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| UMLS_CUI | C1511894
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