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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2156
http://purl.obolibrary.org/obo/NCIT_C2156
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|---|---|
| Preferred Name | Duocarmycin Antineoplastic Antibiotic |
| Definitions |
A spirocyclopropylhexadienone-containing antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A spirocyclopropylhexadienone-containing antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. |
|---|---|
| prefLabel | Duocarmycin Antineoplastic Antibiotic
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| label | Duocarmycin Antineoplastic Antibiotic
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| code | C2156
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| prefixIRI | NCIT:C2156
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| Preferred_Name | Duocarmycin Antineoplastic Antibiotic
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| Legacy Concept Name | Duocarmycin_Antibiotic
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| type | |
| subClassOf | |
| Semantic_Type | Chemical Viewed Functionally
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| UMLS_CUI | C1512091
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