Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

E3 Ubiquitin-Protein Transferase
Synonyms
Definitions

An ATP-dependent aminoacyltransferase that catalyzes the third step in the ubiquitination reaction via the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to lysine residues found in the final substrate protein.
ID

http://purl.obolibrary.org/obo/NCIT_C21254
code

C21254
definition

An ATP-dependent aminoacyltransferase that catalyzes the third step in the ubiquitination reaction via the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to lysine residues found in the final substrate protein.
DesignNote

The IUBMB has recategorized E3 ubiquitin-protein ligases as transferases (EC 2). There are 2 categories of E3 enzymes based on the structure of the active site: HECT-type (EC 2.3.2.26) and RING-type (EC 2.3.2.27).
label

E3 Ubiquitin-Protein Transferase
Legacy Concept Name

E3_Ubiquitin_Ligase
NCI_META_CUI

CL449066
Preferred_Name

E3 Ubiquitin-Protein Transferase
prefixIRI

NCIT:C21254
prefLabel

E3 Ubiquitin-Protein Transferase
Semantic_Type

Amino Acid, Peptide, or Protein

Enzyme
subClassOf

http://purl.obolibrary.org/obo/NCIT_C16259
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