Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C20946
http://purl.obolibrary.org/obo/NCIT_C20946
Preferred Name

Baculoviral IAP Repeat-Containing Protein 3
Definitions
Baculoviral IAP repeat-containing protein 3 (604 aa, ~68 kDa) is encoded by the human BIRC3 gene. This protein is involved in the inhibition of apoptosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Baculoviral IAP repeat-containing protein 3 (604 aa, ~68 kDa) is encoded by the human BIRC3 gene. This protein is involved in the inhibition of apoptosis.
prefLabel
Baculoviral IAP Repeat-Containing Protein 3
label
Baculoviral IAP Repeat-Containing Protein 3
code
C20946
prefixIRI
NCIT:C20946
OMIM_Number
601721
in_subset
Display_Name
Baculoviral IAP Repeat-Containing Protein 3
Preferred_Name
Baculoviral IAP Repeat-Containing Protein 3
Contributing_Source
CTRP
Swiss_Prot
Q13489
Legacy Concept Name
Baculoviral_IAP_Repeat-Containing_Protein-3
DesignNote
Encoded by BIRC3 Gene (IAP Family) Baculoviral IAP Repeat-Containing Protein 3 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
type
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
UMLS_CUI
C0763658
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