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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C20934
http://purl.obolibrary.org/obo/NCIT_C20934
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|---|---|
| Preferred Name | IAP Family Protein |
| Definitions |
A family of proteins that are related structurally and functionally and are inhibitors of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A family of proteins that are related structurally and functionally and are inhibitors of apoptosis. |
|---|---|
| prefLabel | IAP Family Protein
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| label | IAP Family Protein
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| code | C20934
|
| prefixIRI | NCIT:C20934
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| in_subset | |
| Display_Name | IAP Family Protein
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| Preferred_Name | IAP Family Protein
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| Contributing_Source | CTRP
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| Legacy Concept Name | IAP_Family_Protein
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| DesignNote | IAP Family Proteins exhibit an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C0893445
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| Delete | Subject | Author | Type | Created |
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| No notes to display |