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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2083
http://purl.obolibrary.org/obo/NCIT_C2083
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|---|---|
| Preferred Name | DNA Methyltransferase Inhibitor |
| Definitions |
Any substance that inhibits DNA methyltransferase, an enzyme required for DNA methylation. Inhibition of DNA methyltransferase results in hypomethylation of genomic DNA and cell cycle arrest at S-phase. Hypomethylation in malignant cells may also restore suppressor gene expression and re-establish controlled growth and differentiation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Any substance that inhibits DNA methyltransferase, an enzyme required for DNA methylation. Inhibition of DNA methyltransferase results in hypomethylation of genomic DNA and cell cycle arrest at S-phase. Hypomethylation in malignant cells may also restore suppressor gene expression and re-establish controlled growth and differentiation. |
|---|---|
| prefLabel | DNA Methyltransferase Inhibitor
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| label | DNA Methyltransferase Inhibitor
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| NCI_META_CUI | CL1642980
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| code | C2083
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| prefixIRI | NCIT:C2083
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| Preferred_Name | DNA Methyltransferase Inhibitor
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| Legacy Concept Name | DNA_Methyltransferase_Inhibitor
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| type | |
| subClassOf | |
| Semantic_Type | Chemical Viewed Functionally
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