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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C20646
http://purl.obolibrary.org/obo/NCIT_C20646
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|---|---|
| Preferred Name | Topoisomerase |
| Definitions |
Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin. |
|---|---|
| label | Topoisomerase
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| prefLabel | Topoisomerase
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| Legacy Concept Name | Topoisomerase
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| Preferred_Name | Topoisomerase
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| UMLS_CUI | C1336767
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| prefixIRI | NCIT:C20646
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| subClassOf | |
| code | C20646
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| type | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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