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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2062
http://purl.obolibrary.org/obo/NCIT_C2062
|
|---|---|
| Preferred Name | Pan-RAR Agonist/AP-1 Inhibitor LGD 1550 |
| Definitions |
An orally-active synthetic aromatic retinoic acid agent with potential antineoplastic and chemopreventive activities. LGD 1550 selectively binds to all three retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression of genes responsible for cell differentiation and proliferation. This agent also acts as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses and malignant transformation. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active synthetic aromatic retinoic acid agent with potential antineoplastic and chemopreventive activities. LGD 1550 selectively binds to all three retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression of genes responsible for cell differentiation and proliferation. This agent also acts as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses and malignant transformation. (NCI04) |
|---|---|
| prefLabel | Pan-RAR Agonist/AP-1 Inhibitor LGD 1550
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| label | Pan-RAR Agonist/AP-1 Inhibitor LGD 1550
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| code | C2062
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| prefixIRI | NCIT:C2062
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| in_subset | |
| Preferred_Name | Pan-RAR Agonist/AP-1 Inhibitor LGD 1550
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| Maps_To | Pan-RAR Agonist/AP-1 Inhibitor LGD 1550
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| CAS_Registry | 178600-20-9
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| Legacy Concept Name | LGD_1550
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1517688
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