Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C2057
http://purl.obolibrary.org/obo/NCIT_C2057
Preferred Name

Lapuleucel-T
Definitions
A cell-based vaccine targets tumors expressing the HER2/neu marker. HER-2/neu is a growth factor receptor, and its overexpression has been associated with a number of cancers including breast, ovarian, colon and lung cancers. APC8024 comprise of autologous antigen-presenting peripheral blood mononuclear cells (APCs) that have been exposed to HER2/neu protein and can be administered to the patient. These cells may stimulate an antitumor T-cell response to cancer cells expressing HER2/neu. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A cell-based vaccine targets tumors expressing the HER2/neu marker. HER-2/neu is a growth factor receptor, and its overexpression has been associated with a number of cancers including breast, ovarian, colon and lung cancers. APC8024 comprise of autologous antigen-presenting peripheral blood mononuclear cells (APCs) that have been exposed to HER2/neu protein and can be administered to the patient. These cells may stimulate an antitumor T-cell response to cancer cells expressing HER2/neu. (NCI04)
label
Lapuleucel-T
prefLabel
Lapuleucel-T
Legacy Concept Name
APC_8024
in_subset
Preferred_Name
Lapuleucel-T
Is_Value_For_GDC_Property
Display_Name
Lapuleucel-T
Maps_To
Lapuleucel-T
PDQ_Open_Trial_Search_ID
735849
UMLS_CUI
C1515856
FDA_UNII_Code
J5Z87L8ROA
prefixIRI
NCIT:C2057
NCI_Drug_Dictionary_ID
735849
Contributing_Source
CTRP
FDA
subClassOf
code
C2057
type
PDQ_Closed_Trial_Search_ID
735849
Semantic_Type
Pharmacologic Substance
Immunologic Factor
CAS_Registry
845680-07-1
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