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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C20514
http://purl.obolibrary.org/obo/NCIT_C20514
|
|---|---|
| Preferred Name | Interleukin-12 |
| Definitions |
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI) |
|---|---|
| label | Interleukin-12
|
| prefLabel | Interleukin-12
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| Legacy Concept Name | Interleukin-12
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| in_subset | |
| Preferred_Name | Interleukin-12
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| Display_Name | Interleukin-12
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| UMLS_CUI | C0123759
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| prefixIRI | NCIT:C20514
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C20514
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| type | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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