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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Interleukin-10 | |
| Synonyms |
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| Definitions |
Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C20512 |
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| ALT_DEFINITION |
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine.
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| code |
C20512
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| Contributing_Source |
CTRP
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| definition |
Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression.
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| DesignNote |
Interleukin-10 down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.
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| Display_Name |
Interleukin-10
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Interleukin-10
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| Legacy Concept Name |
Interleukin-10
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| OMIM_Number |
124092
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| Preferred_Name |
Interleukin-10
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| prefixIRI |
NCIT:C20512
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| prefLabel |
Interleukin-10
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| Semantic_Type |
Amino Acid, Peptide, or Protein Immunologic Factor
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| Swiss_Prot |
P22301
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| UMLS_CUI |
C1699802
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| subClassOf |
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