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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2051
http://purl.obolibrary.org/obo/NCIT_C2051
|
|---|---|
| Preferred Name | Spongistatin |
| Definitions |
A highly cytotoxic macrocyclic lactone polyether with antitumor activity. Spongistatin, originally isolated from marine Spongia species, binds to the vinca domain of tubulin, thereby interferes with microtubule assembly and results in inhibition of mitosis. This agent does not affect the binding of colchicine to tubulin, but it was a potent inhibitor of the binding of vinblastine and GTP to tubulin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A highly cytotoxic macrocyclic lactone polyether with antitumor activity. Spongistatin, originally isolated from marine Spongia species, binds to the vinca domain of tubulin, thereby interferes with microtubule assembly and results in inhibition of mitosis. This agent does not affect the binding of colchicine to tubulin, but it was a potent inhibitor of the binding of vinblastine and GTP to tubulin. |
|---|---|
| prefLabel | Spongistatin
|
| label | Spongistatin
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| code | C2051
|
| prefixIRI | NCIT:C2051
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| in_subset | |
| Preferred_Name | Spongistatin
|
| Maps_To | Spongistatin
|
| CAS_Registry | 148179-94-6
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| Legacy Concept Name | Spongistatin
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| PubMedID_Primary_Reference | 8232226
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0248118
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