Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Acyclovir | |
| Synonyms |
|
|
| Definitions |
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C205 |
|
| ALT_DEFINITION |
A substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals.
|
|
| CAS_Registry |
59277-89-3
|
|
| CHEBI_ID |
CHEBI:2453
|
|
| Chemical_Formula |
C8H11N5O3
|
|
| code |
C205
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization.
|
|
| Display_Name |
Acyclovir
|
|
| FDA_UNII_Code |
X4HES1O11F
|
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Acyclovir
|
|
| Legacy Concept Name |
Acyclovir
|
|
| NCI_Drug_Dictionary_ID |
39134
|
|
| NCI_META_CUI |
CL523878
|
|
| NSC Number |
335752 645011
|
|
| PDQ_Closed_Trial_Search_ID |
39134
|
|
| PDQ_Open_Trial_Search_ID |
39134
|
|
| Preferred_Name |
Acyclovir
|
|
| prefixIRI |
NCIT:C205
|
|
| prefLabel |
Acyclovir
|
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping