Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C2049 http://purl.obolibrary.org/obo/NCIT_C2049
Preferred Name	Indibulin
Definitions	A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.
prefLabel	Indibulin
label	Indibulin
PDQ_Closed_Trial_Search_ID	587341
code	C2049
prefixIRI	NCIT:C2049
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Indibulin
FDA_UNII_Code	80K4H2RB8P
Contributing_Source	FDA
Chemical_Formula	C22H16ClN3O2
Maps_To	Indibulin
CAS_Registry	204205-90-3
NCI_Drug_Dictionary_ID	587341
Legacy Concept Name	D_24851
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C25974
PDQ_Open_Trial_Search_ID	587341
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C1956330

Delete	Subject	Author	Type	Created
No notes to display