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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Transforming Growth Factor Beta-2 | |
| Synonyms |
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| Definitions |
Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C20458 |
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| code |
C20458
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| Contributing_Source |
CTRP
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| definition |
Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways.
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| DesignNote |
TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)
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| Display_Name |
Transforming Growth Factor Beta-2
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Transforming Growth Factor Beta-2
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| Legacy Concept Name |
Transforming_Growth_Factor_Beta-2
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| OMIM_Number |
190220
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| Preferred_Name |
Transforming Growth Factor Beta-2
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| prefixIRI |
NCIT:C20458
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| prefLabel |
Transforming Growth Factor Beta-2
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P61812
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| UMLS_CUI |
C1699342
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| subClassOf |
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