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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C20458
http://purl.obolibrary.org/obo/NCIT_C20458
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|---|---|
| Preferred Name | Transforming Growth Factor Beta-2 |
| Definitions |
Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways. |
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| prefLabel | Transforming Growth Factor Beta-2
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| label | Transforming Growth Factor Beta-2
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| code | C20458
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| prefixIRI | NCIT:C20458
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| OMIM_Number | 190220
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| in_subset | |
| Display_Name | Transforming Growth Factor Beta-2
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| Preferred_Name | Transforming Growth Factor Beta-2
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| Contributing_Source | CTRP
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| Swiss_Prot | P61812
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| Legacy Concept Name | Transforming_Growth_Factor_Beta-2
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| DesignNote | TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C1699342
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