loading...| Preferred Name | Transforming Growth Factor Alpha | |
| Synonyms |
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| Definitions |
Transforming growth factor alpha (50 aa, ~6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C20454 |
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| code |
C20454 |
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| definition |
Transforming growth factor alpha (50 aa, ~6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation. |
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| DesignNote |
The active form of the growth factor, transforming growth factor alpha, is produced when proteolytic cleavage removes 39 amino acids from the N-terminus and 71 amino acids from the C-terminus of protransforming growth factor alpha. The precursor is a transmembrane protein and the mature form is a secreted protein. (UniProt) In esophageal adenocarcinoma patients who received high-dose radiation and chemotherapy, tumors that either persistently expressed or had increased TGFA expression was associated with a worse prognosis. (Int J Radiat Oncol Biol Phys. 1995; 31:567-9.) |
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| label |
Transforming Growth Factor Alpha |
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| Legacy Concept Name |
Transforming_Growth_Factor_Alpha |
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| OMIM_Number |
190170 |
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| Preferred_Name |
Transforming Growth Factor Alpha |
|
| prefixIRI |
NCIT:C20454 |
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| prefLabel |
Transforming Growth Factor Alpha |
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| PubMedID_Primary_Reference |
7852121 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein |
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| Swiss_Prot |
P01135 |
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| UMLS_CUI |
C3849193 |
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| subClassOf |