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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C20450
http://purl.obolibrary.org/obo/NCIT_C20450
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|---|---|
| Preferred Name | Vascular Endothelial Growth Factor A |
| Definitions |
Vascular endothelial growth factor A (232 aa, ~27 kDa) is encoded by the human VEGFA gene. This protein plays a role in both cell proliferation and angiogenesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Vascular endothelial growth factor A (232 aa, ~27 kDa) is encoded by the human VEGFA gene. This protein plays a role in both cell proliferation and angiogenesis. |
|---|---|
| prefLabel | Vascular Endothelial Growth Factor A
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| label | Vascular Endothelial Growth Factor A
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| code | C20450
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| prefixIRI | NCIT:C20450
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| OMIM_Number | 192240
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| in_subset | |
| Display_Name | Vascular Endothelial Growth Factor A
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| Preferred_Name | Vascular Endothelial Growth Factor A
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| Contributing_Source | CTRP
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| Swiss_Prot | P15692
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| Legacy Concept Name | Vascular_Endothelial_Growth_Factor
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| DesignNote | The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon. (UniProt)
Vascular endothelial growth factor A has multiple protein isoforms that range from ~15 kDa to ~27 kDa and are the result of alternative splicing. The isoforms are denoted by the term VEGF followed by the number of amino acids contained therein. This entry uses VEGF206 to represent the canonical vascular endothelial growth factor A.
Encoded by human VEGF Gene (PDGF/VEGF Family), widely expressed 232-amino acid 27 kD (precursor) VEGF exhibits seven isoforms: VEGF206, -189, -183, -165/VEGF, -148, -145, and -121. VEGF121 is acidic; VEGF165 is more basic and binds heparin/ECM; VEGF189 is very basic. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein angiogenic growth factor; it may heterodimerize with PLGF. VEGF inhibits apoptosis and promotes endothelial proliferation, cell migration, and vascular permeabilization. VEGF interacts with VEGFR1/FLT-1 and VEGFR2/KDR/FLK1 receptors. VEGF145 may inhibit -165 binding to FLK1. Collapsin/semaphorin receptor Neuropilin-1 (VEGF165R) mediates neuronal cell guidance and binds VEGF165 and -145, but not -121; it enhances VEGF165/KDR binding and chemotaxis. (OMIM, Swiss-Prot, LocusLink, and NCI)
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| type | |
| ALT_DEFINITION | A substance made by cells that stimulates new blood vessel formation.
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| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C1171892
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