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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C2045
http://purl.obolibrary.org/obo/NCIT_C2045
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|---|---|
| Preferred Name | Matrix Metalloproteinase Inhibitor MMI270 |
| Definitions |
An orally-active synthetic hydroxamic acid derivative with potential antineoplastic activity. MMI270 inhibits a broad spectrum of matrix metalloproteinases (MMPs) (specifically MMP-1, 2, 3, 9, and 13), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also downregulate lymphangiogenesis, resulting in decreased lymphatic system-related metastasis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active synthetic hydroxamic acid derivative with potential antineoplastic activity. MMI270 inhibits a broad spectrum of matrix metalloproteinases (MMPs) (specifically MMP-1, 2, 3, 9, and 13), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also downregulate lymphangiogenesis, resulting in decreased lymphatic system-related metastasis. (NCI04) |
|---|---|
| prefLabel | Matrix Metalloproteinase Inhibitor MMI270
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| label | Matrix Metalloproteinase Inhibitor MMI270
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| code | C2045
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| prefixIRI | NCIT:C2045
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| in_subset | |
| Preferred_Name | Matrix Metalloproteinase Inhibitor MMI270
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| Maps_To | Matrix Metalloproteinase Inhibitor MMI270
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| Legacy Concept Name | MMI270
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0385829
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