Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C20442
http://purl.obolibrary.org/obo/NCIT_C20442
Preferred Name

Insulin-Like Growth Factor
Definitions
Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential autocrine ligands) involved in mediation of growth hormone action, stimulation of insulin action, and growth and development. The three main somatomedins are Somatomedin C (IGF1), Somatomedin A (IGF2), and Somatomedin B. Single chain IGFs I and II share about 47% amino acid homology with insulin (INS) and 31% with relaxin.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential autocrine ligands) involved in mediation of growth hormone action, stimulation of insulin action, and growth and development. The three main somatomedins are Somatomedin C (IGF1), Somatomedin A (IGF2), and Somatomedin B. Single chain IGFs I and II share about 47% amino acid homology with insulin (INS) and 31% with relaxin.
prefLabel
Insulin-Like Growth Factor
label
Insulin-Like Growth Factor
code
C20442
prefixIRI
NCIT:C20442
in_subset
Display_Name
Insulin-Like Growth Factor
Preferred_Name
Insulin-Like Growth Factor
Contributing_Source
CTRP
Legacy Concept Name
Insulin-Like_Growth_Factor
type
ALT_DEFINITION
A protein made by the body that stimulates the growth of many types of cells. IGF is similar to insulin (a hormone made in the pancreas). There are two forms of IGF called IGF-1 and IGF-2. Higher than normal levels of IGF-1 may increase the risk of several types of cancer. IGF is a type of growth factor and a type of cytokine.
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Hormone
UMLS_CUI
C0037657
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