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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Epidermal Growth Factor | |
| Synonyms |
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| Definitions |
Epidermal growth factor (53 aa, ~6 kDa) is encoded by the human EGF gene. This protein is involved in mitogenesis and magnesium reabsorption. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C20425 |
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| ALT_DEFINITION |
A protein made by many cells in the body and by some types of tumors. It causes cells to grow and differentiate (become more specialized). It is a type of growth factor and a type of cytokine.
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| code |
C20425
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| Contributing_Source |
CTRP
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| definition |
Epidermal growth factor (53 aa, ~6 kDa) is encoded by the human EGF gene. This protein is involved in mitogenesis and magnesium reabsorption.
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| DesignNote |
The active form of the growth factor, epidermal growth factor, is produced by two proteolytic cleavage events that remove 970 N-terminal amino acids and 184 amino acids from the C-terminus of pro-epidermal growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt)
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| Display_Name |
Epidermal Growth Factor
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Epidermal Growth Factor
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| Legacy Concept Name |
Epidermal_Growth_Factor
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| OMIM_Number |
131530
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| Preferred_Name |
Epidermal Growth Factor
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| prefixIRI |
NCIT:C20425
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| prefLabel |
Epidermal Growth Factor
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| Semantic_Type |
Amino Acid, Peptide, or Protein Hormone
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| Swiss_Prot |
P01133
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| UMLS_CUI |
C0242275
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| subClassOf |
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