Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C2039 http://purl.obolibrary.org/obo/NCIT_C2039
Preferred Name	Bevacizumab
Definitions	A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels.
Type	http://www.w3.org/2002/07/owl#Class

definition	A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels.
prefLabel	Bevacizumab
label	Bevacizumab
PDQ_Closed_Trial_Search_ID	43234
code	C2039
Has_Target	http://purl.obolibrary.org/obo/NCIT_C20450
prefixIRI	NCIT:C2039
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	Bevacizumab
Preferred_Name	Bevacizumab
FDA_UNII_Code	2S9ZZM9Q9V
Contributing_Source	CTRP FDA
Maps_To	Bevacizumab
CAS_Registry	216974-75-3
NSC Number	704865
NCI_Drug_Dictionary_ID	43234
Legacy Concept Name	Bevacizumab
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A drug used to treat several types of cancer, including certain types of colorectal, lung, breast, and kidney cancers and glioblastoma. It is also being studied in the treatment of other types of cancer. Avastin binds to vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2496 http://purl.obolibrary.org/obo/NCIT_C129822
PDQ_Open_Trial_Search_ID	43234
Accepted_Therapeutic_Use_For	Metastatic Colorectal Cancer, Non-small Cell Lung Cancer, glioblastoma; Metastatic Renal Cell Carcinoma; persistent, recurrent or metastatic cervical cancer; epithelial ovarian, fallopian tube, or primary peritoneal cancer
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
UMLS_CUI	C0796392

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