loading...| Preferred Name |
Aclarubicin |
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| Synonyms |
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| Definitions |
An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C202 |
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| CAS_Registry |
57576-44-0 |
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| Chemical_Formula |
C42H53NO15 |
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| code |
C202 |
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| Contributing_Source |
FDA |
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| definition |
An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. |
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| FDA_UNII_Code |
74KXF8I502 |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Aclarubicin |
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| Legacy Concept Name |
Aclarubicin |
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| Maps_To |
Aclarubicin |
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| NCI_Drug_Dictionary_ID |
39131 |
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| NSC Number |
208734 240619 |
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| PDQ_Closed_Trial_Search_ID |
39131 |
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| PDQ_Open_Trial_Search_ID |
39131 |
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| Preferred_Name |
Aclarubicin |
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| prefixIRI |
NCIT:C202 |
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| prefLabel |
Aclarubicin |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
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| UMLS_CUI |
C0001143 |
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| subClassOf |