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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C202
http://purl.obolibrary.org/obo/NCIT_C202
|
|---|---|
| Preferred Name | Aclarubicin |
| Definitions |
An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin. |
|---|---|
| prefLabel | Aclarubicin
|
| label | Aclarubicin
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 39131
|
| code | C202
|
| prefixIRI | NCIT:C202
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| in_subset | |
| Preferred_Name | Aclarubicin
|
| FDA_UNII_Code | 74KXF8I502
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| Contributing_Source | FDA
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| Chemical_Formula | C42H53NO15
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| Maps_To | Aclarubicin
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| CAS_Registry | 57576-44-0
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| NSC Number |
208734
240619
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| NCI_Drug_Dictionary_ID | 39131
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| Legacy Concept Name | Aclarubicin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39131
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0001143
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| Delete | Subject | Author | Type | Created |
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