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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1968
http://purl.obolibrary.org/obo/NCIT_C1968
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|---|---|
| Preferred Name | Topoisomerase-II Inhibitor |
| Definitions |
Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis. |
|---|---|
| prefLabel | Topoisomerase-II Inhibitor
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| label | Topoisomerase-II Inhibitor
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| CHEBI_ID | CHEBI:50750
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| code | C1968
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| prefixIRI | NCIT:C1968
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| Preferred_Name | Topoisomerase-II Inhibitor
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| Legacy Concept Name | Topoisomerase-II_Inhibitor
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| type | |
| subClassOf | |
| Semantic_Type | Chemical Viewed Functionally
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| UMLS_CUI | C1519554
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