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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C19672
http://purl.obolibrary.org/obo/NCIT_C19672
|
|---|---|
| Preferred Name | Histone Deacetylase 3 |
| Definitions |
Histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone deacetylation and signal regulation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone deacetylation and signal regulation. |
|---|---|
| prefLabel | Histone Deacetylase 3
|
| label | Histone Deacetylase 3
|
| code | C19672
|
| prefixIRI | NCIT:C19672
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| OMIM_Number | 605166
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| in_subset | |
| Display_Name | Histone Deacetylase 3
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| Preferred_Name | Histone Deacetylase 3
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| Contributing_Source | CTRP
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| Swiss_Prot | O15379
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| Legacy Concept Name | Histone_Deacetylase-3
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| DesignNote | HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity to yeast Hda1 deacetylase. HDAC3 may regulate transcription through binding the zinc-finger transcription factor YY1, increasing its repression activity. RELA is a nonhistone substrate of HDAC3. IKBA-dependent nuclear export of deacetylated RELA replenishes the cytoplasmic pool of NFKB/IKBA complexes for NFKB responses. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (OMIM)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C1098658
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