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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C19671
http://purl.obolibrary.org/obo/NCIT_C19671
|
|---|---|
| Preferred Name | Histone Deacetylase 1 |
| Definitions |
Histone deacetylase 1 (482 aa, ~55 kDa) is encoded by the human HDAC1 gene. This protein is involved in chromatin remodeling and the negative regulation of apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Histone deacetylase 1 (482 aa, ~55 kDa) is encoded by the human HDAC1 gene. This protein is involved in chromatin remodeling and the negative regulation of apoptosis. |
|---|---|
| prefLabel | Histone Deacetylase 1
|
| label | Histone Deacetylase 1
|
| code | C19671
|
| prefixIRI | NCIT:C19671
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| OMIM_Number | 601241
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| in_subset | |
| Display_Name | Histone Deacetylase 1
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| Preferred_Name | Histone Deacetylase 1
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| Contributing_Source | CTRP
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| Swiss_Prot | Q13547
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| Legacy Concept Name | Histone_Deacetylase-1
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| DesignNote | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. This protein belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C1334032
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