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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C195
http://purl.obolibrary.org/obo/NCIT_C195
|
|---|---|
| Preferred Name | Mercaptopurine |
| Definitions |
A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04) |
|---|---|
| prefLabel | Mercaptopurine
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| label | Mercaptopurine
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| CHEBI_ID | CHEBI:31822
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| PDQ_Closed_Trial_Search_ID | 43436
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| code | C195
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| prefixIRI | NCIT:C195
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| in_subset |
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| Display_Name | Mercaptopurine
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| Preferred_Name | Mercaptopurine
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| FDA_UNII_Code | E7WED276I5
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C5H4N4S.H2O
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| Maps_To | Mercaptopurine
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| CAS_Registry | 6112-76-1
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| NSC Number | 755
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| NCI_Drug_Dictionary_ID | 43436
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| Legacy Concept Name | Mercaptopurine
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| type | |
| ALT_DEFINITION | A drug used to treat acute lymphatic leukemia. It belongs to the family of drugs called antimetabolites.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43436
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| Accepted_Therapeutic_Use_For | Acute lymphocytic leukemia; Acute myelogenous leukemia; Crohns disease; Hodgkins lymphoma in children; Lymphoblastic lymphoma; Ulcerative colitis
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C0000618
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