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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1941
http://purl.obolibrary.org/obo/NCIT_C1941
|
|---|---|
| Preferred Name | Recombinant Tumor Necrosis Factor Family Protein |
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF) proteins. TNF family cytokines bind to and activate specific cell-surface receptors, thereby mediating inflammatory processes, cell proliferation, immunity, angiogenesis, and tumor cell cytotoxicity. One primary antitumor effect of TNFs involves stimulation of T cell-mediated antitumor cytotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant therapeutic agent which is chemically identical to or similar to one of a number of endogenous tumor necrosis factor (TNF) proteins. TNF family cytokines bind to and activate specific cell-surface receptors, thereby mediating inflammatory processes, cell proliferation, immunity, angiogenesis, and tumor cell cytotoxicity. One primary antitumor effect of TNFs involves stimulation of T cell-mediated antitumor cytotoxicity. |
|---|---|
| prefLabel | Recombinant Tumor Necrosis Factor Family Protein
|
| label | Recombinant Tumor Necrosis Factor Family Protein
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| PDQ_Closed_Trial_Search_ID | 40250
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| code | C1941
|
| prefixIRI | NCIT:C1941
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| in_subset | |
| Display_Name | Recombinant Tumor Necrosis Factor Family Protein
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| Preferred_Name | Recombinant Tumor Necrosis Factor Family Protein
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| Contributing_Source | CTRP
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| NSC Number |
349993
604175
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| NCI_Drug_Dictionary_ID | 40250
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| Legacy Concept Name | Therapeutic_Tumor_Necrosis_Factor_Family_Protein
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| type | |
| ALT_DEFINITION | A protein made by white blood cells in response to an antigen (substance that causes the immune system to make a specific immune response) or infection. Tumor necrosis factor can also be made in the laboratory. It may boost a person's immune response, and also may cause necrosis (cell death) of some types of tumor cells. Tumor necrosis factor is being studied in the treatment of some types of cancer. It is a type of cytokine.
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| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40250
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1522668
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