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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C192
http://purl.obolibrary.org/obo/NCIT_C192
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|---|---|
| Preferred Name | Mesna |
| Definitions |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04) |
|---|---|
| prefLabel | Mesna
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| label | Mesna
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| PDQ_Closed_Trial_Search_ID | 39759
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| code | C192
|
| prefixIRI | NCIT:C192
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| in_subset |
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| Display_Name | Mesna
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| Preferred_Name | Mesna
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| FDA_UNII_Code | NR7O1405Q9
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C2H5O3S2.Na
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| Maps_To | Mesna
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| CAS_Registry | 19767-45-4
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| NSC Number | 113891
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| NCI_Drug_Dictionary_ID | 39759
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| Legacy Concept Name | Mesna
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| type | |
| ALT_DEFINITION | A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39759
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| Accepted_Therapeutic_Use_For | Ifosfamide-induced hemorrhagic cystitis, prophylaxis
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0000294
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| Delete | Subject | Author | Type | Created |
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