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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1888
http://purl.obolibrary.org/obo/NCIT_C1888
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|---|---|
| Preferred Name | Isocoumarin NM-3 |
| Definitions |
An orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity. NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation. This agent also induces apoptosis by a mechanism involving reactive oxygen species. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity. NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation. This agent also induces apoptosis by a mechanism involving reactive oxygen species. (NCI04) |
|---|---|
| label | Isocoumarin NM-3
|
| prefLabel | Isocoumarin NM-3
|
| Legacy Concept Name | NM-3
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| in_subset | |
| Preferred_Name | Isocoumarin NM-3
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| Is_Value_For_GDC_Property | |
| Maps_To | Isocoumarin NM-3
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| PDQ_Open_Trial_Search_ID | 355804
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| UMLS_CUI | C1122058
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| FDA_UNII_Code | 5797K23F95
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| prefixIRI | NCIT:C1888
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| NCI_Drug_Dictionary_ID | 355804
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| Contributing_Source | FDA
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| subClassOf | |
| code | C1888
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| type | |
| PDQ_Closed_Trial_Search_ID | 355804
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 181427-78-1
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