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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1884
http://purl.obolibrary.org/obo/NCIT_C1884
|
|---|---|
| Preferred Name | Orantinib |
| Definitions |
An orally bioavailable receptor tyrosine kinase inhibitor. SU6668 binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. SU6668 also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable receptor tyrosine kinase inhibitor. SU6668 binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. SU6668 also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. (NCI04) |
|---|---|
| prefLabel | Orantinib
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| label | Orantinib
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| PDQ_Closed_Trial_Search_ID | 38421
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| code | C1884
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| Has_Target | |
| prefixIRI | NCIT:C1884
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| in_subset |
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| Display_Name | Orantinib
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| Preferred_Name | Orantinib
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| FDA_UNII_Code | 9RL37ZZ665
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C18H18N2O3
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| Maps_To | Orantinib
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| CAS_Registry | 252916-29-3
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| NSC Number | 702827
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| NCI_Drug_Dictionary_ID | 38421
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| Legacy Concept Name | SU6668
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called angiogenesis inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38421
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0960373
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