Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1881
http://purl.obolibrary.org/obo/NCIT_C1881
Preferred Name

Motexafin Gadolinium
Definitions
A synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating reactive oxygen species (ROS) intracellularly and lowering the tumor cell apoptotic threshold to ionizing radiation and chemotherapy. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating reactive oxygen species (ROS) intracellularly and lowering the tumor cell apoptotic threshold to ionizing radiation and chemotherapy. (NCI04)
prefLabel
Motexafin Gadolinium
label
Motexafin Gadolinium
CHEBI_ID
CHEBI:50162
CHEBI:50161
PDQ_Closed_Trial_Search_ID
42391
code
C1881
prefixIRI
NCIT:C1881
in_subset
Display_Name
Motexafin Gadolinium
Preferred_Name
Motexafin Gadolinium
FDA_UNII_Code
6433A42F4F
Contributing_Source
CTRP
FDA
Chemical_Formula
C48H66N5O10.2C2H3O2.Gd
Maps_To
Motexafin Gadolinium
CAS_Registry
156436-89-4
NSC Number
695238
NCI_Drug_Dictionary_ID
42391
Legacy Concept Name
Motexafin_Gadolinium
type
ALT_DEFINITION
A substance that is being studied in the treatment of cancer. It may make tumor cells more sensitive to radiation therapy, improve tumor images using magnetic resonance imaging (MRI), and kill cancer cells. It is a type of metalloporphyrin complex.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42391
Semantic_Type
Organic Chemical
Pharmacologic Substance
Indicator, Reagent, or Diagnostic Aid
UMLS_CUI
C0964264
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