Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1874
http://purl.obolibrary.org/obo/NCIT_C1874
Preferred Name

Pipendoxifene
Definitions
A nonsteroidal 2-phenyl indole and a selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Pipendoxifene antagonizes binding of estradiol to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression, interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent breast cancer. In addition, this agent also exerts intrinsic estrogenic activity depending on the tissue types.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A nonsteroidal 2-phenyl indole and a selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Pipendoxifene antagonizes binding of estradiol to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression, interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent breast cancer. In addition, this agent also exerts intrinsic estrogenic activity depending on the tissue types.
prefLabel
Pipendoxifene
label
Pipendoxifene
PDQ_Closed_Trial_Search_ID
38112
code
C1874
prefixIRI
NCIT:C1874
in_subset
Preferred_Name
Pipendoxifene
FDA_UNII_Code
TPC5Q8496G
Contributing_Source
FDA
Chemical_Formula
C29H32N2O3
Maps_To
Pipendoxifene
CAS_Registry
198480-55-6
NCI_Drug_Dictionary_ID
38112
Legacy Concept Name
ERA_923
type
ALT_DEFINITION
A substance that is being studied as a treatment for cancer. It belongs to a family of drugs called antiestrogens.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38112
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0935699
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display